Biopharmaceutic and Pharmacokinetic Books A Treatise PDF
The same drug is administered as different dosage forms or similar dosage forms produced by different manufacturers, which in turn depend upon the physicochemical properties of the drug, the excipients present in the dosage form, the method of formulation and the manner of administration.
A new and separate discipline called biopharmaceutics has therefore been developed to account for all such factors that influence the therapeutic effectiveness of a drug.
Defination – Biopharmaceutics is defined as the study of factors influencing the rate and amount of drug that reaches the systemic circulation and use of this information to optimize the therapeutic efficacy of the drug
*The process of movement of drug from its site of administration to the systemic circulalion is called as absorption.
*Bioavailability – is defined as the rate and extent (amount) of drug absorption. Any alteration in the drug’s bioavailability is reflected in its phamacologic effects. Other processes that play a role in the therapeutic activity of a drug are distribution and elimination.
Pharmacokinetics is defined as the study of time course of drug ADME( Absorption, Distribution, Metabolism, Elimination ) & their relationship with its therapeutic and toxic effect of the drug.
*Simply speaking, pharmacokinetics is the kinetics of ADME or KADME. The use of pharmacokinetic principles in optimizing the drug dosage to suit individual patient needs and achieving maximum therapeutic utility is called as clinical pharmacokinetics.
Book suitable for pharmacy students –
This is the standard book in pharmacy. The twin discipline of biopharmaceutic and pharmacokinetics have therefore been developed with the objective of learning how drug can be utilize optimally in the treatment of diseases to design and development of new and better therapeutic moieties new dosage from and appropriate dosage regimens.
Significant expansion of the chapter on controlled release medication has been made to cover in a border perspective the principal employed in the design of such dosge from their classification and brief description of the technology and product delivered by varous routes.
- 1. Introduction.
- 2. Absorption of drug
- 3. Distribution if drug
- 4 . Protein binding of drug .
5. Biotransfermation of drug.
- 6. Prodrugs
- 7. Excretion of drug.
- 8. Pharmacokinetic drug interactions .
- 9. Pharmacokinetic basic considerations.
- 10. Compartment modeling
- 11. Non linear pharmacokinetics
- 12. Bioavailability and Bioequivalence.
- 13. Application of pharmacokinetic Principales.
- 14. Drug concentration and pharmacological response .
- 15. Controlled release medication.
PDF INFO –
Book’s Name – Biopharmaceutic and Pharmacokinetic Books A Treatise
Author – D. M. Brahmanakar, Sunil B. Jaiswal
Publishers – Delhi ; Vallabh Prakashan, 2005, 1995.
Size of PDF – 55.90 MB
Number of pages – 206
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