Goodman & Gilman’s The Pharmacological basis of Therapeutic twelfth Edition

What Is pharmacology?

Pharmacology is the science of drugs (Greek:Pharmacon-drug; logos discourse in). In a broad sense, it deals with interaction of exo-genously administered chemical molecules with living systems, or any single chemical substance which can produce a biological response is a ‘drug’. It encompasses all aspects of knowledge about drugs, but most importantly those that are relevant to effective and safe use for medicinal purposes.

Pharmacology as an experimental science was ushered by Rudolf Buchheim who founded the first institute of pharmacology in 1847 in Germany. In the later part of the 19th century, Oswald Schmiedeberg, regarded as the “father of pharmacology”, together with his many disciples like J Langley, T Frazer, P Ehrlich, AJ Clark, JJ Abel propounded some of the fundamental concepts in pharmacology. Since then drugs have been purified, chemically characterized and a vast variety of highly potent and selective new drugs have been developed.

The two main divisions of pharmacology are :

(A). Pharmacodynamics and

(B). Pharmacokinetics.

Pharmacodynamics :

(Greek: dynamis—power) — What the drug does to the body.

This includes physiological and biochemical effects of drugs and their mechanism of action at organ system/subcellular macromolecular levels,

e.g.
Adrenaline → interaction with adrenoceptors → G-protein mediated stimulation of cell membrane bound adenylyl cyclase → increased intracellular cyclic 3´,5´AMP → cardiac stimulation, hepatic glycogenolysis and hyperglycaemia, etc.

Pharmacokinetics :

(Greek: Kinesis—movement)—What the body does to the drug.

This refers to movement of the drug in and alteration of the drug by the body; includes absorption, distribution, binding/localization/storage, bio transformation and excretion of the drug.

Overview – Goodman & Gilman’s The Pharmacological basis of therapeutic offer concise, authoritative coverage of class specific and diseases specific drug, organised primarily by organ /system. Derived from Goodman & Gilman’s pharmacological basis of therapeutic , twelfth edition and this streamlined focuses on the principal
Of medical pharamacology and drug therapy & delivers coverage of all major drug classes;

More than a pocket drug guide, this powerful resource covers:

  • Genral principal
  • Neuro pharmacology
  • Modulation of cardiovascular, pulmonary and renal function.
  • inflammation, immunomodulation and hematopoiesis.
  • Hormones band Hormone antagonists
  • Drug affecting gastrointestinal function.
  • Chemotherapy of microbial diseases
  • Chemotherapy of neoplastic diseases

    The text explains the physiology and pathophysiology of major organ system and pathogens with respect to Pharmacotherapy and mechanism of Drug action. With a new full colour design numerous tablet charts and
    illustration that highlight explain and summarize important information, Goodman & Gilman’s manual of pharmacology and therapeutic is essential wherever knowledge of drug action and intraction is required nursing, pharmacy and medical student will find the manual to be a concise and authoritative text book.

    Objective of this book – Three objectives have guided the writing of this book the correlation of pharmacology with related medical sciences, the reinterpretation of the actions and uses of drugs from the viewpoint of important advances in
    medicine, and the placing of emphasis on the applications of pharmacodynamics to therapeutics.

    Although pharmacology is a basic medical science in its own right, it borrows freely from and contributes generously to the subject matter and technics of many medical disciplines, clinical as well as preclinical. Therefore, the correlation of strictly pharmacological information with medicine as a whole is essential for a proper presentation of pharmacology to students and physicians.

    BOOK INFO : Goodman & Gilman’s The Pharmacological basis of Therapeutic

    About the author – Laurence L, Bronton, PhD Professor of pharmacology and Medicine University of California, san Diego.

    (Laurence Bronton trained under
    Alfred Goodman – Gilman and is nationally recognized for his expertise in cell signalling and cardiovascular pharmacology . He has published more than 200 original research paper)

    Content-

    Section I

      *Genral principles

    • 1. Drug invention and the haemaceutical industrial
    • 2. Pharmacokinetic : Absorption, Distribution ,Metabolism, Elimination.
    • 3.Pharmacodynamic : Molecular Mechanism of Drug action.

    *more other chapers avilable in section I

    Section II

      *Neuropharmacology

    • 8. Neurotransmission : Autonomic and Somatic, motor nervs system.
    • 9. Muscarinic receptor agonist and antagonists.
    • 10. Anticholinergic agents

    *more other chapers avilable in section II

    Section III

      *Modulation of cardiovascular function

    • 25.Regulation of renal function and vascular volume.
    • 26. Renin and Angiotensin.
    • 27.Treatment of Myocardial Ischemia and hypertension.
    • 28. Pharmacotherapy of congestive heart failure.

    *more other chapers avilable in section III

    Section IV

      *Inflammation, Immunomodulation, and hematopoiesis

    • 32 .Histamine, Bradykinin, and The Antagonists..
    • 33. Lipid-Derived Autacoids: Eicosanoids and Platelet Activating Factor
    • 34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout ..
    • 35.Immunosuppressants, Tolerogens, and Immunostimulants.

    *more other chapers avilable in section IV

    Section V

      *Hormones and Hormone Antagonists

    • 38. Introduction To Endocrinology: The Hypothalamic-Pituitary Axis..
    • 39. Thyroid and Anti-Thyroid Drugs.
    • 40. Estrogens and Progestins.

    *more other chapers avilable in section V

    Section VI

      *Drug Affecting Gastrointestinal function

    • 45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers.

    *more other chapers avilable in section VI

    Section VII

      *Chemotherapy of microbial diseases

    • 48.General Principles of Antimicrobial Therapy.
    • 49.Chemotherapy of Malaria.

    *more other chapers avilable in section VII

    Section VIII

      *Chemotherapy of neoplastic diseases

    • 60. General Principles of Cancer Chemotherapy..
    • 61. Cytotoxic Agents..

    *more other chapers avilable in section VIII

    Secton IX

      *Special system pharmacology

    • 64. Ocular Pharmacology..
    • 65. Dermatological Pharmacology

    *more other chapers avilable in section

    PDF INFO :

    Book’s Name : Goodman & Gilman’s The Pharmacological basis of Therapeutic
    Edition : Twelfth Edition
    Authors : Laurence Brunton. Bruce chabner, Bjorn knollman.
    Size of PDF : 25.69 MB
    Number of Pages : 2108 Pages

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